代表性论著

(#代表第一作者或共同第一作者,*代表通讯作者或共同通讯作者)

1. Lin L(#), Ke H(#*), Chen M(#), Zhang Y(#), Fu S, Yu F, Su J, Yang X, Guo Y, Ding Q, Zhang Y, Zhao L(*). Downregulation of TDP-43 by atovaquone inhibits oxidative phosphorylation and enhances sensitivity of triple-negative breast cancer to EGFR-TKIs. Free Radical Biology and Medicine. 2026. doi.org/10.1016/j.freeradbiomed.2026.03.047. …NEWS  

 

2. Chen M(#), Xiao T(#), Ke H(#), Ye C, Yu F, Su J, Yang S, Feng Y, Xu H, Fu S, Lin L, Lin J, Xie Y, Ding Q, Qiu Y, Yu R, Lv H, Li W, Zhang Y, Ding Z, Zou Y(*), Yuan H(*), Zhao L(*). Age-related aberrant alternative splicing as a prognostic tool in older breast cancer patients. Communications Biology. 2025 Dec 16. doi: 10.1038/s42003-025-09330-y.    …NEWS  

 

3. Lin J(#), Qiu Y(#),Ye C, Zhang Y, Zeng Z, Yao B, Hu Y, Zhao L(*). RNA and protein degradation in the aging process. Cellular Signalling. 2025 Dec:136:112166. doi: 10.1016/j.cellsig.2025.112166.  

 

4. Wu X(#), Chen M (#), Liu K (#), Wu Y (#), Feng Y, Fu S, Xu H, Zhao Y, Lin F, Lin L, Ye S, Lin J, Xiao T, Li W, Lou M, Lv H, Qiu Ye, Yu R, Chen W, Li M, Feng X, Luo Z, Guo L, Ke H(*), Zhao L (*).Molecular classification of geriatric breast cancer displays distinct senescent subgroups of prognostic significance. Molecular Therapy Nucleic Acids. 2024. Aug 15;35(4):102309. doi: 10.1016/j.omtn.2024.102309.    …NEWS  

 

5. Fu S#,Ke H#,Yuan H, Xu H, Chen W, Zhao L*. Dual role of pregnancy in breast cancer risk. Gen Comp Endocrinol. 2024; 23: 114501. doi: 10.1016/j.ygcen.2024.114501.

 

6. Ke H#, Liu K, Jiao B*, Zhao L*. Implications of TDP-43 in non-neuronal systems. Cell Commun Signal. 2023;  21(1):338.

 

7. Lin J#, Ye S#, Ke H#, Lin L, Wu X, Guo M, Jiao B*, Chen C*, Zhao L*. Changes in the mammary gland during aging and its links with breast diseases. Acta Biochimica et Biophysica Sinica.2023: 1001–1019. doi: 10.3724/abbs.2023073.

 

8. Guo L#, Ke H#, Zhang H, Zou L, Yang Q, Lu X, Zhao L* and Jiao B*. TDP43 promotes stemness of breast cancer stem cells through CD44 variant splicing isoforms. Cell Death Dis. 2022 (CDDIS-21-3957R, DOI: 10.1038/s41419-022-04867-w).

 

9. Zhao L#, Ke H#, Xu H, Wang G, Zhang H, Zou L, Xiang S, Li L, Ao L, Yang Q, Shen CK, Yi P*, Wang L*, Jiao B*. TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh. Nature Communications. 2020. 11(1): p. E341.

 

10. Zhao L(#), Li L(#), Xu H, Ke H, Zou L, Yang Q, Shen CJ, Nie J(*), Jiao B(*). TDP-43 is Required for Mammary Gland Repopulation and Proliferation of Mammary Epithelial Cells. Stem Cells and Development. 2019; 28(14):944-953